Drugdiscovery相关论文
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Proteostasis (protein homeostasis) ensures precise adjustment of cellular demand to proteins in the stress conditions,wh......
离子通道是极具潜力的药物靶点.近年来,越来越多的新的离子通道靶标在疾病中被发现,比如:疼痛、心血管疾病以及神经系统疾病.尽管......
Improvement of Kidney Yang Syndrome by Icariin through Regulating Hypothalamus-Pituitary-Adrenal Axi
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Discovery of covalent ligands via non-covalent docking by dissecting covalent docking based on a par
Covalent ligands modulating protein activities/signals have attracted unprecedented attention in recent years,but the in......
Zebrafish as a vertebrate animal model is increasingly used for in vivo drug discovery and for assessing drug toxicity a......
Relevant Component Analysis as a Data Pre-processing Method for in Silico Toxicity Prediction in Dru
Background: Toxicities of potential drug candidates is one of the main focuses in the drug discovery process.However, th......
Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 sign
Activation of Wnt/β-catenin signaling can enhance mTORC1 signaling in cancer cells.The low density lipoprotein receptor......
Most lymphocytes in psoriatic lesions are effector memory T (TEM) cells that express high levels of Kv1.3,a subtype of v......
The low success rate, despite a huge capital investment, has made the research and development of conventional drugs ver......
Development of High Performance Autosampler for Front-end UHPLC to Improve LC/MS and LC/MS/MS Analys
To speed up R&D in such areas as pharmacokinetics and synthesis in drug discovery, it has become increasingly necessary ......
Drug addiction is a serious problem,which causes serious medical and social problems.Currently there is no effective way......
In the past thirty years,SBDD has made very important impact to drug discovery.At Hengrui,SBDD is used routinely for our......
Traditional Chinese Medicine(TCM)holds great potential for treating various diseases for thousands of years....
Ethenesulfonyl Fluoride(ESF):A Versatile Sulfur(Ⅵ)Fluoride Exchange(SuFEx)Click Chemistry Hub and Mo
Sulfur(Ⅵ)fluoride exchange(SuFEx)represents the latest and one of the most powerful reactions in click chemistry.SuFEx ......
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Objective:Osteoporosis has become the biggest cause of non-fatal health issue.Currently,the limitations of traditional a......
Protein-protein and protein-nucleic acid interfaces have been regarded as "undruggable" despite their importance in ......
Drug Resistance of Antianrogens and Discovery of Novel Androgen Receptor Antagonists from Natural Pr
Prostate cancer(PCa),an epithelial malignancy that occurs in the prostate,reminds the second leading cause of cancer......
Structure Difference-Oriented Design of Selective Butyrylcholinesterase Probe and Its Application in
The two major human cholinesterases,acetylcholinesterase(AChE; EC 3.1.1.7)and butyrylcholinesterase(BChE; EC 3.1.1.8......
Alkyne moieties widely exist in natural products isolated from plants and marine organisms and pharmaceuticals as im......
Bioassay guided separation of bioactive components in natural products via counter-current chromatog
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Drug safety is one of the key issues in the future realization of precision medicine.However,the molecular basis of ......
Marine organisms possess the capacity to produce a variety of unique and biologically potent natural products for tr......
Chitosan oligosaccharides,novel natural activators of calcium-activated chloride channels(CaCCs)TMEM
Background: Calcium-activated chloride channels(CaCCs)/TMEM16A control diverse fundamental physiological functions,a......
虚拟筛选是新药研发流程中的重要方法,该方法利用计算机技术模拟药物筛选的过程,极大提高了新药研发的效率.虚拟筛选过程会产生大......
Modulating balance of synaptic and extrasynaptic NMDA receptors as strategy for Alzheimer disease dr
The unbalance between synaptic(GluN2A,mediating the protective pathway)and extra-synaptic NMDA receptors(NMDARs)(Glu......
It is increasingly accepted that enzyme promiscuity is not a rare phenomenon; rather,it appears to be widespread and......
Covalent ligands modulating protein activities/signals have attracted unprecedented attention in recent years,but th......
Drug discovery,from its traditional area of lead discovery and optimization,has extended toward two directions: upst......
Perspectives and challenges of tropical medicinal herbs and modern drug discovery in the current sce
Tropical diseases such as malaria, tuberculosis, trypanosomiasis, and leishmaniasis, account for a large number of death......
Viral diseases were largely untreatable 40 years ago.The first antivirals were developed in the 1960s, mostly to deal w......
天然产物是药物发现与筛选的物质基础，高效、快速的药物筛选技术是获得天然产物线索化合物的重要前提。本文从药物研发环境、药物研......
Epithelial-mesenchymal transition (EMT) is a natural phenomenon thatoccurs during embryodevelopment. It is a phenomenon ......
